Human rights, health and development represent interdependent sets of values, aspirations and disciplines. Drawing on these domains, this paper offers a theoretical and practical framework for the analysis, application and assessment of health, justice and progress. It provides a simple conceptual framework illustrating the interdependence of these domains and highlights their key features and underlying principles. It then describes the reciprocal interactions between health, development and human rights and suggests how these linkages can be analysed and applied in practice. A Health, Development and Human Rights Impact Assessment (HDHR IA) approach is proposed to guide and monitor policies and programs towards maximising synergy.